… a peripherally restricted opioid receptor … opioids by colitogenic CD4 + T cells present in the
mucosa. This mini‐review provides a brief overview of analgesia by immune‐derived opioids …

… central nervous system (CNS) penetration (and therefore a reduced side effect profile) yet
maintaining the desired opioid-related peripheral antinociceptive activity. These include highly …

… Additionally, intrathecal morphine results in a reduction in the number of β-endorphin-containing
cells within the inflamed tissues, and peripheral endogenous antinociceptive effects are …

… Immune-derived opioids exhibit anti-inflammatory activities in Th1/Th17-driven colitis because
of their propensity to favor the commitment of lymphocytes towards a Th2 phenotype [45,…

… in which the mucosal opioid tone is dramatically reduced … colonic sensory afferents by
immune-derived opioids in IBS, β-… be hypothesized that a reduced opioid tone delays mucosal …

… a novel antinociceptive strategy exploiting the opioid-mediated … -methiodide, a peripheral
opioid receptor antagonist. Similarly, … We show opioid-dependent analgesic properties of local …

… In this review, we discuss the influence of either opioids or non-opioid analgesics used
under opioid-free anesthesia (OFA) on the immune response to surgical stress as described in …

… by the simultaneous action of several immune-derived ligands upon nociceptors. This explains
the … effect of IMT504 over other endogenous opioid peptides. Even though lymphoid cells …

… Endorphin, encephalin, and dynorphin, known as endogenous opioids or opioid peptides,
are … Opioid substances exerted a chief immunosuppressive effect on anti-tumor immunity …

… In acute inflammation, opioid peptides are almost … the opioid peptide is released, it acts on
the corresponding receptors of peripheral sensory nerve endings to trigger antinociception[12]…